TGFB1 and neoplasm: We have developed a mechanobiological explanation for this phenomenon, the mechanosensitive protein PC1 has been found to be associated with the generation of certain tumours, integrins mediate bone metastasis in breast, prostate and lung cancers by promoting cancer cell adhesion, migration and survival, activation of YAP has also been associated with bone metastasis [111], and mechanically stimulated production of the TGF-β family such as BMP is closely associated with tumour metastasis.