KLF5 and hepatocellular carcinoma: To understand the relationship between up-regulated KLF5 and HCC (Fig. 1B), the intracellular localization of KLF5 in human HCC tissues (Fig. 1C) was determined, and the circulating levels of KLF5 in patients with chronic liver diseases were quantitatively investigated to analyze its clinical value and explore the mechanism underlying KLF5 promoting HCC progression.