In this study, hepatic KLF5 and Wnt3a (Fig. 1F) were clearly expressed in the same cells, and because of their cellular localization, cross-talk between KLF5 and Wnt3a (Fig. 1G) might represent another novel mechanism (Fig. 1H) closely related to HCC progression. The gene discussed is KLF5; the disease is hepatocellular carcinoma.