AKT1 and cancer: As a transcriptional activator, KLF5 can regulate gene transcription, the cell cycle, and cell proliferation and differentiation and plays a pivotal role in the regulation of cancer stem-like cells and the promotion of cell growth and metastasis by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/Snail signaling pathway in HCC.