Although we cannot firmly conclude that mutations in the spike protein of Beta VOC may impact antibody detection by COVID-19 serology assays that use the spike as the target, our findings are consistent with Reincke et al., which described reduced ELISA positivity and neutralization of 40 serum samples from patients infected with the Beta VOC compared to an ancestral strain [38]. This evidence concerns the gene CHMP5 and COVID-19.