Angiotensin II downregulated genes involved in anti-inflammatory pathways such as Dusp1 and Btg2. Overexpression of Dusp1 attenuates inflammation in a mouse model of cardiomyopathy (Tan et al., 2022) while deficiency of Dusp1 has been shown to exacerbate inflammation in a mouse model of septic peritonitis (Hammer et al., 2010). Here, DUSP1 is linked to cardiomyopathy.