YK-4-279, which blocks the EWS-FLI1 transcription factor, effectively kills p53-deficient colorectal cancer cells with the BRAFV600E mutation (like RKO) by stopping ETS1 increase and causing a parthanatos-like cell death involving overactive PARP1, mitochondrial damage, and AIF moving to the nucleus (67). The gene discussed is PARP1; the disease is colorectal cancer.