As shown in Figures 11G and 11H, both the average tumor volume and weight were significantly decreased in the TMEM86B knockdown groups compared to their respective controls (RKO/shNC vs. RKO/shTMEM86B; HCT116/shNC vs. HCT116/shTMEM86B), indicating that TMEM86B down-regulation suppresses tumor growth in vivo. The gene discussed is TMEM86B; the disease is neoplasm.