NFKB1 and glaucoma: By analyzing evidence of Sinomenine's (SIN) anti-fibrotic effects across multiple organs, this study explores its potential use in glaucoma filtration surgery (GFS) to reduce scarring: (1) SIN inhibits trauma-induced NF-κB activation in Tenon's fibroblasts (TFs), reduces neutrophil and macrophage infiltration, and suppresses cytokine cascades.