GPT and chronic obstructive pulmonary disease: Figure 2 illustrated the non-linear relationship SII and the incidence of CHD in participants diagnosed with asthma, adjusting for variables such as BMI, ALT, AST, smoking status, cancer, hypertension, high cholesterol, diabetes, arthritis, gout, stroke, and thyroid problems, chronic bronchitis, emphysema and COPD (Figure 2A).