In recent years, studies have reported that the ratio of C-reactive protein to prealbumin (CPR) and the ratio of fibrinogen to prealbumin (FPR) have significant clinical value in the diagnosis and prognosis assessment of inflammatory and neoplastic diseases (Wang et al., 2020; Ying et al., 2021; Maruyama et al., 2022; Guo et al., 2025). This evidence concerns the gene TTR and neoplasm.