EWSR1 and Ewing sarcoma: For instance, chromosomal translocations such as EML4-ALK, KIF5B-RET, and CD74-ROS1 (Jiang et al., 2021; Yeung et al., 2022), which are present in lung adenocarcinoma, as well as the EWSR1-FLI1 translocation in Ewing sarcoma and the RUNX1-ETO translocation in acute myelogenous leukemia (Cervera et al., 2021), have been successfully reconstructed in cellular models using CRISPR/Cas9 technology.