The NYU team systematically identified 46 key long-chain non-coding RNAs (e.g., MALAT1, MIR17HG) that regulate cancer progression through transcriptome-scale CRISPR-Cas13 screening, in which knockdown of MALAT1 inhibits tumor metastasis, while the regulation of MIR17HG affects cell cycle progression (Liang et al., 2024). The gene discussed is MIR17HG; the disease is cancer.