In contrast, the control group’s Achilles tendon tissue exhibited typical tendinopathy pathological features, such as disorganized arrangement of collagen bundles, fragmentation of collagen fibers, fat infiltration and the ingrowth of neovessels, which was observed a gradation of therapeutic reversal in the low, medium, and high dosage groups of NGR1. This evidence concerns the gene RTN4R and disease of the tendon.