On the surface of tumor cells, the TF-FVIIa complex generates pro-angiogenic factors, such as VEGF, through protease-activated receptor 2 (PAR2)-mediated intracellular signaling pathways, thereby stimulating tumor angiogenesis (Kocatürk and Versteeg, 2013), (Schaffner and Ruf, 2009). This evidence concerns the gene F2RL1 and neoplasm.