Mesothelin binds to mucin16/carbohydrate antigen 125 (Kaneko et al., 2009), downregulates Dickkopf-1 (an inhibitor of the Wnt signaling pathway) through the serum and glucocorticoid-regulated kinase 3 (SGK3)/forkhead box O3 (FoxO3) signaling pathway, and activates the Wnt/β-catenin axis, thereby promoting cancer cell metastasis (Huo et al., 2021). The gene discussed is FOXO3; the disease is cancer.