Soluble Nectin-4 further promotes inositol polyphosphate 4-phosphatase type II-dependent lysosomal degradation via the PI3K/AKT axis, which activates the Wnt/β-catenin signaling pathway, driving the proliferation and metastasis of BC cells (Kedashiro et al., 2019; Siddharth et al., 2017; Rodgers et al., 2023). The gene discussed is NECTIN4; the disease is breast cancer.