In this study, to comprehensively understand the pathogenic molecular mechanisms of epigenetic and epitranscriptomic expression in SARS-CoV-2 infection, an in vitro SARS-CoV-2-infected hiPSC-CM model was used to assess the pivotal role of TET2-mediated epitranscriptomics and RNA modification in the replication and infection process of SARS-CoV-2 (Figs. 2 to 4). The gene discussed is TET2; the disease is infection.