In this study, using hiPSC-CMs as an in vitro infectious myocarditis model for SARS-CoV-2 infection, we found that endogenous TET2 expression and TET2-mediated m5C hydroxylation were significantly up-regulated as part of the epitranscriptomic modifications following SARS-CoV-2 infection. Here, TET2 is linked to infectious disease.