Diabetic nephropathy (DN) is known as a serious microvascular complication of diabetes and is the leading cause of end-stage renal disease (ESRD) (123, 124), which is characterized by glomerulosclerosis, tubular atrophy, and fibrosis, concomitant with oxidative stress and NF-κB signaling activation (125). The gene discussed is NFKB1; the disease is liver dysplastic nodule.