Specific subclasses, such as flavones (e.g., apigenin and luteolin), flavonols (e.g., quercetin and kaempferol), flavanones (e.g., naringenin), and isoflavones (e.g., genistein and daidzein), have shown the ability to inhibit tumor growth, modulate androgen receptor (AR) signaling, and reverse aberrant DNA methylation and histone modification in PCa models (7–10). The gene discussed is AR; the disease is posterior cortical atrophy.