The characteristic presentation of APS is venous and/or arterial thrombosis, any organ system or vessel may be impacted by one or more events, concurrently or consecutively.18 In a meta-analysis19 totalling 16 441 patients, it was found that aPL, particularly LA and aCL, increased significantly the risk of venous thrombosis. The gene discussed is ACLY; the disease is Venous thrombosis.