In particular, LPS can lead to an increase in ROS(Beutler, 2004; Pchejetski et al., 2011), which can mediate MMP-3-induced EMT and genomic instability (Radisky et al., 2005); Unfolded Protein Response (UPR), as one of the most important adaptive systems of tumor cells, can adapt to external stimuli by integrating multiple signaling pathways to promote tumor cell survival, and has been shown to be associated with EMT (Shen et al., 2015). The gene discussed is MMP3; the disease is neoplasm.