TP53 and cancer: In the above analysis, the process of increased Riskscore scores was accompanied by enrichment of cancer cell proliferation metastasis-related pathways, lower levels of immune cell infiltration, and higher TMB; the high-risk subgroup demonstrated significant signal generation of epithelial-mesenchymal transition and mutational signals associated with invasion (e.g., TP53 mutations), results that may contribute to a low-benefit effect in tumor immunotherapy.