PROGENy enrichment analysis further validated the molecular pathway differences between the two subgroups, and showed that the high-scoring subgroup received significant enrichment in pathways related to tumor progression and metastasis, including EGFR, Hypoxia, JAK-STAT, MAPK, NFkB, PI3K, TNFa, Trail, VEGF and WNT pathways (Figure 3H). This evidence concerns the gene TNF and neoplasm.