Our RNA seq analysis also confirmed that the expression levels of eight genes (BAX, CCNE1, E2F1, E2F2, FADD, IKBKE, IRF7, STAT1) were higher in breast cancer tissues than those in normal tissues, and the expression levels of seven genes (AKT3, CASP12, CREB5, MAPK11, PIK3R1, TGFBR2, TRAF6) were lower in breast cancer tissues than those in normal tissues (Fig. 6, Table S6). This evidence concerns the gene CREB5 and breast cancer.