KEGG pathway analysis found that the DEGs were mainly involved in the toll-like receptor signaling pathway, MAPK signaling pathway, TNF signaling pathway, JAK-STAT signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, T cell receptor signaling pathway, FoxO signaling pathway and apoptosis (Table S3–4). The gene discussed is CD274; the disease is cancer.