Furthermore, by analyzing how GER affects the expression of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), and NO levels during PTZ-induced clonic seizures, the study also aimed to fill the gap regarding the potential mechanisms underlying the anticonvulsant properties of GER and pave the way for therapeutic advances. Here, NOS2 is linked to gastroesophageal reflux disease.