The growing body of research on the relationship between VEGF and PF has shown that VEGF can promote the progression of PF by increasing the expression of MMPs and participating in the PI3K/Akt signaling pathway, the JAK2/STAT3 signaling pathway, macrophage inflammation, hypoxia regulation, and multiple TGF-β1 pathways [36–41]. Here, STAT3 is linked to pemphigus foliaceus.