- Killing cancer cells by granule exocytosis and apoptosis stimulated by death ligands in the cells such as TRAIL-FasL- Induction of cytotoxicity through the release of IFN-γ and TNFα- IFN-γ production induces M1 polarity of macrophages and release of chemokines to attract CD4+ T cells.- Release of TNFα promotes anti-M2 polarization of macrophages. Here, CD4 is linked to cancer.