CD4 and neoplasm: -Cross-presentation of MHC class I antigens by DCs to CD8+ T-cells induces the generation of CTLs.-Ligand interactions on DCs CD70 and CD80-CD86) and receptors on CD8+ T cells (CD27 and CD28) play a key role in priming CD8 + T cells.-Leaded by cytokines (CXCL9 and CXCL10) secreted by DCs CTLs migrate into the tumor.-IFN-γ stimulates the production of CTLs-Promotion by CD4+ T-cells-Stimulatory checkpoints (CD40L, etc.)