- Weakening the translocation of CTLs to the tumor nucleus- TGF-β release and suppression of CTLs activity- Expression of CD73 on the surface contributes to Treg-mediated inhibition of CTLsimmunosuppressive activity- CTLA-4-mediated suppression of antigen-presenting cells- Consumption of IL-2- Release of anti-inflammatory cytokines (IL-10, TGFβ). Here, TGFB1 is linked to neoplasm.