In some SjD mouse models such as the NOD.B10-H2b and C57BL/6.NOD-Aec1Aec2 mice, salivary gland dysfunction and sialadenitis can be detected as early as 12 weeks of age (55, 56), whereas SjD-like pathologies appear at 12–14 months of age in BAFF/BLyS transgenic mice (57). This evidence concerns the gene TNFSF13B and sialadenitis.