TTR and amyloidosis: These agents function by binding specifically to TTR tetramers, thereby reducing the propensity of TTR to dissociate into monomers, which is a critical step in the pathogenesis of TTR amyloidosis.45 46 By stabilising TTR in its native tetrameric form, these stabilisers mitigate the accumulation of misfolded TTR protein and subsequent amyloid deposition in various tissues.