ITGB2(+) macrophages demonstrated significantly higher signaling intensity than ITGB2(-) macrophages in both RA and MN (Figure 7A,B,F,G), acting as senders (GALECTIN, CCL, BAFF; Figure 7C,H) and receivers (CCL, GAS, COMPLEMENT, GALECTIN; Figure 7D,I). The gene discussed is ITGB2; the disease is rheumatoid arthritis.