Therefore, the aim of this study was to investigate the antibody response against HERV‐W, HERV‐K peptides, and MOG in the cerebrospinal fluid (CSF) of MS patients, to determine whether distinct HERVs peptides could induce different humoral response and to compare whether MS patients shows distinct humoral response than patients without neuroinflammatory diseases such as idiopathic intracranial hypertension (IIH). The gene discussed is MOG; the disease is pseudotumor cerebri.