The release of adipocyte factors, notably leptin and adiponectin, plays a critical role in driving the metabolic changes and inflammatory responses associated with disc degeneration.[12,13] Furthermore, obesity is linked to significantly elevated levels of IL-6 and pro-inflammatory cascades throughout the body, contributing to the inflammation-mediated pathway of disc degeneration.[14]. This evidence concerns the gene ADIPOQ and intervertebral disk degenerative disorder.