Studies have shown that SPEN mutations are enriched in DLBCL cases failing to achieve event-free survival at 24 months (EFS24), contrasting with generally favorable outcomes in BN2 subtype tumors.[15] The TMSB4X protein is involved in regulating the intracellular actin cytoskeleton, crucial for cell migration, proliferation, and differentiation. Here, SPEN is linked to diffuse large B-cell lymphoma.