Mutations in NOTCH2 allow escape from ubiquitin-dependent degradation, promoting chemoresistance in DLBCL.[11] Mutations in CREBBP/EP300 induce H3K27 deacetylation, which negatively affects the NOTCH signaling pathway by dysregulating the NOTCH repressor FBXW7. The gene discussed is CREBBP; the disease is diffuse large B-cell lymphoma.