INSR and type 2 diabetes mellitus: A Venn diagram identified 10 shared targets between the GQD targets and the genes related to T2DM and CRC (Fig. 4C): ADRA1B (adrenergic receptor alpha 1B), CALM1 (calmodulin 1), CDKN2A (cyclin-dependent kinase inhibitor 2A), CTNNA1 (cadherin-associated protein, alpha 1), FCER2 (Fc fragment of IgE receptor II), GSR (glutathione reductase), GSTM1 (glutathione S-transferase mu 1), IL13 (interleukin 13), INSR (insulin receptor), and MAPK9 (mitogen-activated protein kinase 9, also known as JNK2).