DNM1L and Insulin resistance: These alterations in β cells may be closely linked to changes in mitochondrial dynamics, leading to impaired insulin secretion in response to glucose stimulation.[129,130] In T2DM, the processes of β-cell fusion and fission undergo continuous modification; studies indicate that elevated blood glucose and palmitate levels reduce fusion events and inhibit mitochondrial oxygen consumption.[131,132] Drp1-mediated mitochondrial fission may be a contributing factor to insulin resistance.