However, Lee V showed that voriconazole increased oxidative stress in keratinocytes by directly inhibiting catalase leading to lower intracellular NADPH levels.[15] Therefore, we hypothesize that the increased oxidative stress from voriconazole has potential clinical value as a “second hit” in causing dasatinib-induced pulmonary arterial hypertension. The gene discussed is CAT; the disease is pulmonary arterial hypertension.