One of these findings is that dasatinib-related pulmonary arterial hypertension is associated with Src protein kinase family which were crucial for TWIK (tandem of P domains in a weak inwardly rectifying K+ channel)-related acid sensitive potassium 1 potassium channel functioning.[9] Decreasing TWIK-related acid sensitive potassium 1 activity caused by inhibition of SRC kinases resulted in intracellular calcium level increase thus enhancing vasoconstriction and vascular remodeling. Here, KCNJ1 is linked to pulmonary arterial hypertension.