PHGDH is highly expressed in various cancers and promotes tumor progression, and its inhibitors can suppress the growth of multiple cancers, increasing sensitivity to chemotherapy drugs.[48–57] However, reducing serine levels or inhibiting PHGDH hinders the toxicity and pro-apoptotic effects of cisplatin on gastric cancer cells.[58] The mechanisms by which serine metabolism affects chemotherapy sensitivity in gastric cancer may differ from other cancers. The gene discussed is PHGDH; the disease is cancer.