TCF4 and lung carcinoma: Furthermore, EVs derived from lung cancer exhibit a distinctive expression profile of microRNAs and messenger RNAs, which enhances the transcriptional activity of TCF4/β-catenin and activates the Wnt signaling pathway.[23] Furthermore, they facilitate immune evasion, epithelial-mesenchymal transition, and angiogenesis,[24] thereby playing a crucial role in the formation and metastasis of lung cancer.