MAPT and insomnia: The study emphasizes that BMI may serve as a risk factor for insomnia and neurodegeneration through mechanisms involving metabolic dysregulation and chronic inflammation.[9] RTIs, particularly pneumonia, are associated with systemic inflammation and the production of neurotoxic amyloid-beta and tau proteins, thereby accelerating cognitive deterioration.[10] Blood metabolites (e.g., glucose and lipids) and immune cells (e.g., cytokines and T cells) are implicated in neuroinflammation and the disruption of the blood-brain barrier, processes that are further exacerbated by insomnia.[11]