The KRAS pathway interacts with multiple downstream effectors, such as the RAF-MEK-ERK and PI3K-Akt-mTOR pathways, to regulate diverse cellular functions.[44–46] Moreover, KRAS mutation is closely related to ferroptosis.[47] Ferroptosis is induced in the KRAS-nutant colorectal cancer cells by inhibiting AMPK/AKT/mTOR signaling. The gene discussed is PIK3CA; the disease is colorectal cancer.