Studies have shown that Treg infiltration is associated with BC progression and adverse clinical outcomes.[51] Similarly, although DCs are essential for antigen presentation, their function may be impaired or tolerogenic in the tumor microenvironment, leading to ineffective T cell activation.[52] On the other hand, the reduction in B cells and CD4 + T cells may indicate a weakened adaptive immune response. The gene discussed is CD4; the disease is neoplasm.