PIK3CA and breast cancer: All of these 6 genes have been previously identified as ferroptosis-related genes, among which BRD4 and FLT3 were found to be biomarkers in BC.[14,26] Our data revealed that BRD4, FLT3, and SIAH2 were the protective factors while CS, EMC2, and PIK3CA were the detrimental factors for BC patients.