ABCB1 and lymphangioma: Traditional chemotherapy has a limited role because of the presence of BBB, usually applied to patients with relapsed disease after WBRT.[7] It has been suggested that meningeal metastatic tumors can disrupt the BBB[8] and decrease P-glycoprotein expression, leading to increased permeability of BBB and higher response to chemotherapy.[9] Currently, there are limited reports about the use of systemic chemotherapy for LM.