Furthermore, KEGG analysis revealed that these DRFGs were mostly related to the mammalian target of rapamycin (mTOR), FOXO, and AGE-RAGE signaling pathways in diabetic complications, animal autophagy, fluid shear stress, atherosclerosis, and renal cell carcinoma (Fig. 4B). This evidence concerns the gene RENBP and hereditary clear cell renal cell carcinoma.