Besides acting as a longevity hormone, Klotho could exert diverse anticancer activities by targeting many oncogenic pathways, including the insulin/IGF-1, Wnt, TGF-β1, mammalian target of rapamycin, and essential FGF pathways, some of which are essential for tumor survival and proliferation.[5] Klotho deficiency participated in the development of various types of human malignancies. The gene discussed is KL; the disease is neoplasm.