KL and cancer: In a cohort study of 9879 participants with a follow-up period of 58 months, Qiao et al reported that there was no association between circulating Klotho levels and cancer-specific mortality, as determined by both the fine-gray test and multiple-adjusted Cox regression models.[20] Similarly, Kresovich and Bulka[19] found no significant association between circulating Klotho levels and cancer mortality in a cohort of 10,069 participants using multiple-adjusted Cox regression analysis.