An increase in Klotho activity was reported to cause a disorder characterized by hypophosphatemic rickets and hyperparathyroidism.[34] Some research also indicated that the dosing or timing of Klotho delivery might tip the balance of benefits to harms and affect disorder processes.[6,35,36] The reasons for such findings in cancer patients remain unclear; further elucidation by more studies from basic and clinical perspectives is needed. The gene discussed is KL; the disease is Dent disease.