Serum Klotho below the threshold was associated inversely with cancer mortality, per 1-SD increase of Klotho was associated with a 39% decrease in cancer mortality risk (P = .033); Klotho above the threshold showed a trend for positive association with cancer mortality, per 1-SD Klotho increase was associated with a 22% decrease in cancer mortality (P = .060) (Table 3). Here, KL is linked to cancer.