Klotho below these thresholds was inversely associated with all-cause mortality (Hazard ratio, HR, 95% confidence interval, CI) (0.72, 0.53–0.98) and cancer mortality (0.61, 0.39–0.96); Klotho above the threshold showed a trend of positive associated with cancer mortality (1.22, 0.99–1.50). This evidence concerns the gene KL and cancer.