NR4A1 and breast cancer: Endocrine therapy is predominantly used in patients with hormone receptor-positive breast cancer, either as adjuvant treatment to prevent recurrence and metastasis following surgery or as a salvage therapy in cases of recurrence and metastasis.[21] By lowering estrogen levels or blocking the interaction between estrogen and hormone receptors, endocrine therapy effectively inhibits estrogen-dependent breast cancer cell proliferation and tumor growth.[21,22] However, it is also associated with menopausal symptoms, such as hot flushes, sleep disturbances, and vaginal dryness or atrophy.