Notably, Xie et al (2024) leveraged the MR method to prove the causal relationship between CRP and cognitive impairment.[16] And Shi et al (2024) identified a genetic and causal correlation between circulating CRP levels and the risk of lung cancer by using MR methods.[17] Furthermore, Qin et al (2023) explored the causal relationship between CRP and IgA vasculitis through MR method.[18] These pivotal findings underscore the potential of the MR method to offer invaluable insights into devising prevention and treatment strategies for the diseases related to CRP. This evidence concerns the gene CRP and Cognitive impairment.