Many views attribute this phenomenon to an increase in orthopedic infections, an aging population, more invasive procedures, and the growing use of immunosuppressive medicine,[28] while some argue that the risk of SA is related to many intrinsic factors, including old age, diabetes, and chronic diseases.[1] However, there have been numerical observational studies that have highlighted CRP as an independent biomarker for SA and as a systematic marker of inflammation,[12] that is, high levels of CRP may signal persistent inflammation, suggesting an elevated risk of SA. The gene discussed is CRP; the disease is diabetes mellitus.