CRP and Henoch-Schoenlein purpura: Notably, Xie et al (2024) leveraged the MR method to prove the causal relationship between CRP and cognitive impairment.[16] And Shi et al (2024) identified a genetic and causal correlation between circulating CRP levels and the risk of lung cancer by using MR methods.[17] Furthermore, Qin et al (2023) explored the causal relationship between CRP and IgA vasculitis through MR method.[18] These pivotal findings underscore the potential of the MR method to offer invaluable insights into devising prevention and treatment strategies for the diseases related to CRP.