INS and type 2 diabetes mellitus: Although insulin resistance plays a key role in the pathogenesis of type 2 diabetes mellitus (T2DM), clinical cases of insulin resistance in which hyperglycemia remains uncontrolled despite a total insulin daily requirement exceeding 200 IU (or >2 IU/kg) represent rare syndromes.[1] Insulin resistance syndromes (IRS) are conventionally divided into 2 groups: genetic (type A) and immunologic (type B).