TP53 and infection: To start unraveling the molecular mechanisms underlying the detrimental effects of TP53-R273H correction across different cell lines, we performed RNA-seq experiments on three R273H-mutant lines (PANC-1, HT-29, A431). Cell lines expressing the ABE were infected with a virus expressing either a control gRNA or one targeting the driver mutation, and RNA was isolated at 36, 48, and 72 h post infection (p.i.).