Additionally, cytotoxic CXCR3+CD8+-T-cells were found more frequently in PanCK+ tumor areas from L-TTF2 than S-TTF2 patients (42.5% vs. 16.6% of these T-cells localized to tumor cells, P = 0.0042; Fig. 2M; Fig. S4). This evidence concerns the gene CD8A and neoplasm.