The migration of Tregs to the tumor site is also dependent on the process of glucose fermentation and is determined by the activation of glucokinase induced by the surface molecule CD28 upon stimulation of the PI3K-mTORC2 signaling pathway, the hexokinase isoform glucokinase (GCK) is a key element of this process, which mTOR also regulates [380–382]. Here, GCK is linked to neoplasm.