GLS and hepatocellular carcinoma: SUCLA2-coupled succinylation regulation of GLS plays a key role in the regulation of glutamine, which enhances the activity of GLS, leading to the ability of tumor cells to counteract oxidative stress and promote their growth [52], and is also associated with the down-regulation of glutamine transaminase 2 (GOT2) in hepatocellular carcinoma (HCC) cells.