FOLR1 and neurodegenerative syndrome due to cerebral folate transport deficiency: Disruptions in folate transport at this interface, particularly caused by mutations in the FOLR1 gene or the presence of FRα autoantibodies, lead to reduced folate levels in the cerebrospinal fluid (CSF), a key factor in neurodevelopmental disorders such as cerebral folate deficiency (CFD) [14–16].