AGE interaction with receptor for AGEs (RAGE) further increase the expression of VCAM-1, selectins, PAI, and increases endothelial permeability (refer figure 7 for more details of AGE-RAGE interaction in hypertension) increases the risk of cardiovascular problems by promoting LDL oxidation-induced atherosclerosis [691] (Refer Figure 7). Here, AGER is linked to atherosclerosis.