The obesity-associated adipose lipidome shows elevated TAGs with polyunsaturated fatty acids (PUFAs), low saturated fatty acids (SFAs), or mono-unsaturated fatty acids (MUFAs) [311], with few unique lipid metabolites, such as specific 18:2 LPE species, that are elevated in obese people with insulin sensitivity [336]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.