Conversely, the association between RSAT and inflammatory markers along with correlations with insulin resistance and fat mass % (e.g., BIRC3, BCL2A1, IRF1, and NFKBIA) highlights a potential link to metabolic, cardiovascular and chronic kidney diseases with local and/or systemic inflammation as a common denominator and potential mediator. The gene discussed is NFKBIA; the disease is Insulin resistance.