Results revealed dose-dependent effects: compared to the control group, AML decreased Igf1 and Foxo3 mRNA expression (P < 0.01, Fig. 6A, G), while AMM and AMH increased Igf1 but decreased Pten mRNA expression (P < 0.01, Fig. 6D). The gene discussed is IGF1; the disease is acute myeloid leukemia.