PTEN and neoplasm: Gene set enrichment analysis (GSEA) [48] revealed that residual tumors from mice treated with Palbociclib alone displayed a positive enrichment for gene signatures related to drug metabolic mechanisms, KD of the PTEN tumor suppressor, activation of EGFR and KRAS signaling, epithelial-mesenchymal transition, angiogenesis, and hypoxia, and a negative correlation with gene sets associated with the cell cycle, MYC targets, pyrimidine, TCA cycle and fatty acid (FA) metabolism, and DNA replication and repair (Fig. 3A and Supplementary Figs. 4A, B and 5A).