Using (cell-specific) Panx1-deficient mouse models, several studies have demonstrated that PANX1 channels regulate various diseases characterized by an exacerbated inflammatory response, including atherosclerosis (Molica, et al. 2017), stroke (Freitas-Andrade, et al. 2017), and cardiac and renal ischemia/reperfusion injury (Good, et al. 2021; Jankowski, et al. 2018; Rusiecka, et al. 2023). The gene discussed is PANX1; the disease is stroke disorder.