In some cancers that can be associated with inflammation, such as TNBC, mutations causing the loss of p53 function initiate transcription of WNT genes and WNT-dependent expression and secretion of WNT proteins (WNT-1, -6, and -7a) into the extracellular matrix as the initial step in the inflammation process often observed in these types of tumors. The gene discussed is TP53; the disease is cancer.