USP33 is also reported to enhance the protein stability of transforming growth factor beta receptor 2 (TGFBR2) by removing the K63-linked ubiquitin chains on TGFBR2, thereby enhancing transforming growth factor-beta (TGF-beta) signaling and promoting pancreatic cancer cell migration and invasion [41]. This evidence concerns the gene USP33 and familial pancreatic carcinoma.